Endocrine Abstracts

Introduction: Antenatal treatment with dexamethasone in pregnancies affected by congenital adrenal hyperplasias (CAH) therefore suppresses fetal androgen production and prevents virilisation of female infants. Antenatal DXM is reported to be efficacious, preventing or ameliorating virilisation in 80–85% of cases.Case report: 23-year-old patient pregnant at 6 weeks, not known of having congenital adrenal hyperplasia (CAH), concept of consanguineous m...

Introduction: The treatment of Graves’ disease is represented principally by anti-thyroid drugs, radioiodine ablation or thyroidectomy. Methimazole is the most used drug for the initial treatment. It is rare to encounter patients with resistant hyperthyroidism despite high doses of MMI.Case presentation: A 41-year-old woman was referred to our unit for resistant thyrotoxicosis. She had a confirmed Graves’ disease with positive serum Trab. Whils...

Introduction and Backgrounds: Myxedema coma is a severe life threatening form of decompensated hypothyroidism which is associated with a high mortality rate. Infections and discontinuation of thyroid supplements are the major precipitating factors. It’s characterized by a decreased mental status, hypothermia, bradycardia, hypotension, and hypoventilation. Very few cases of Myxedema coma have been reported till date, actual prevalence is unclear with the estimated incidenc...

Introduction: Venous thrombotic disease is a multicausal disease with many powerful risk factors (genetic, hormonal, environmental …). In recent years, several reports suggest possible relationships between hyperthyroidism and risk of venous thrombosis. We report the case of a patient with hyperthyroidism complicated by pulmonary embolism.Case report: A 43-year-old female patient, who’s under treatment for a relapse of Grave’s disease, sh...

Introduction: Graves’ disease is an autoimmune disease, it is considered to be the most common cause of hyperthyroidism. Autoimmune pluriendocrine syndromes include a diverse group of diseases characterized by functional impairment of at least two endocrine glands due to autoimmune events.Material and methods: This is a retrospective hospital record-based study of patients with Graves’ disease followed up in the day hospital of the department o...

Introduction: Hematological toxicity is considered as the main risk of synthetic antithyroid drugs; its major form consists of acute agranulocytosis which can be lethal and requires urgent and adequate management. We report the case of a patient who developed acute agranulocytosis within 1 month of therapy.Observation: A 24-year-old patient with no particular medical history was admitted for management of hyperthyroidism, with a history of weight loss, p...

Introduction: Hypoglycemia is a severe complication of diabetes mellitus characterized by blood sugar levels lower than 0.7 g/L in individuals with diabetes. Several symptoms can be related to hypoglycemia and severe cases can be lethal. Individuals with type 1 diabetes and on insulin therapy may also experience hypoglycemic episodes but their frequency and late occurrence might indicate the presence of autoantibodies to insulin, if no other causes suggest otherwise. This cond...

Introduction: Hypoglycaemia in non diabetic patients is a decrease of blood glucose below a threshold of 0.5 g/l, corresponds to a pathological situation, with many etiologies and whose management constitutes a real challenge, both symptomatic and etiological. The purpose of this study is to highlight the profile of these hypoglycaemia and their management.Patients and method: We have collected cases of hypoglycaemia in non-diabetic subjects encountered ...

Introduction: The prison environment is a space that involves some restrictions. However, diabetic patients require special attention. The aim of this work is to evaluate the impact of this area on the glycemic control and the metabolic profile.Patients and method: Descriptive cross-sectional study carried out on a day of health campaign in a penitentiary center, in the sector for men, and concerned the 62 known diabetic patients of the institution.<...

Introduction: Central diabetes insipidus (DIC) is defined by the excretion of large volume of diluted urine, secondary to an absolute or relative deficiency of endogenous vasopressin. We report three observations of children with central diabetes insipidus.Results: This study reports the case of three patients whose average age was thirteen years old (11, 13 and 15 y). The occurrence of polyuria-polydipsia syndrome was the main reason for consultation an...